Vizz Eye Drops: A Groundbreaking FDA-Approved Advancement in Near Vision

Developed by Lenz Therapeutics, Vizz is the first and only aceclidine-based eye drop approved for this condition. This breakthrough offers millions of adults an opportunity to enjoy clear near vision without the constant dependence on reading glasses, bifocals, or multifocal contact lenses. With more than 128 million Americans affected by presbyopia, experts are calling this approval a paradigm shift in vision correction.

Understanding Presbyopia

Presbyopia is a natural and inevitable condition that occurs as part of the aging process. Typically, it begins to affect people around the age of 40 and gradually worsens into the 50s and 60s. The condition arises when the eye gradually loses its ability to focus on nearby objects. Many individuals first notice symptoms when they start holding books, phones, or menus at arm’s length to see clearly. Other common signs include headaches, eye strain, and blurred near vision, especially during tasks that require close-up focus.

Why Does Presbyopia Happen?

The primary reason behind presbyopia lies in the loss of flexibility of the eye’s lens. In younger eyes, the lens adjusts smoothly to focus on both near and distant objects. However, with age, the lens stiffens, and the ciliary muscles responsible for shifting the lens also lose efficiency. As a result, close-up activities such as reading, sewing, or even scrolling on a smartphone become increasingly difficult. Unlike conditions such as myopia or hyperopia, presbyopia is not caused by the shape of the eye but rather by age-related physiological changes in the lens.

Traditional Solutions

For centuries, presbyopia was managed through external aids and corrective procedures. The most common solution has been reading glasses, often used only for near tasks. Others turn to bifocal or multifocal glasses to correct both near and distant vision. Contact lenses—whether multifocal or monovision—have also provided temporary solutions. In rare cases, laser surgery or lens implants were considered, but these options are expensive and carry surgical risks. Vizz, however, introduces a non-invasive, convenient, and glasses-free alternative that is both effective and safe.

What Is Vizz Eye Drop?

Vizz is based on the active ingredient aceclidine (1.44%), a compound that acts as a pupil-selective miotic. Unlike traditional eye medications, it specifically constricts the pupil without heavily affecting other eye muscles. This leads to what scientists call the “pinhole effect.” By reducing the pupil size to less than 2 millimeters, the depth of focus increases, allowing the eye to see near objects with greater clarity—similar to how a small camera aperture brings more objects into focus.

When used as directed, Vizz is instilled as a once-daily eye drop. Users typically notice improved near vision within 30 minutes, and the effect lasts for up to 10 hours. Importantly, Vizz does not interfere with distance vision, making it one of the most promising treatments ever approved for presbyopia.

Clinical Trial Evidence: The CLARITY Studies

The FDA’s decision to approve Vizz was supported by robust data from three Phase 3 clinical trials known as the CLARITY studies.

In CLARITY 1 and 2, a total of 466 participants used Vizz once daily for 42 days. Results showed a significant improvement in near vision as early as 30 minutes after application. Many participants maintained clear near vision for up to 10 hours without compromising distance vision.

The CLARITY 3 study focused on long-term safety and involved 217 participants over six months. The findings confirmed that daily use of Vizz is safe, effective, and well tolerated with no serious treatment-related adverse events.

Key results revealed that over 70% of users improved by three lines or more on a near vision chart within 30 minutes, while 40% maintained this level of improvement for the entire 10-hour duration.

Benefits of Vizz Eye Drops

Vizz offers a range of benefits that make it a game-changing option in eye care. It is fast-acting, delivering noticeable improvement within half an hour of use. The effect is long-lasting, with many patients enjoying clear near vision for up to 10 hours. Unlike glasses or contact lenses, Vizz provides a glasses-free and non-invasive solution, giving people the freedom to read, work, or use digital devices comfortably. Clinical trials have also demonstrated that it is well tolerated, with most side effects being mild and temporary.

Possible Side Effects of Vizz

While generally safe, Vizz is not without potential side effects. Most are mild and short-lived, including temporary eye irritation, redness, headaches, and mild stinging upon application. Some users may experience slight dimming of vision in low-light conditions due to the smaller pupil size.

In rare cases, more serious complications such as retinal detachment or tears may occur, particularly in patients with pre-existing retinal conditions. Severe allergic reactions are also possible but extremely uncommon. Patients are advised to stop using the drops and consult an eye specialist immediately if they experience symptoms such as flashes of light, sudden vision loss, or curtain-like shadows in their field of vision.

Who Should Avoid Vizz?

Vizz may not be appropriate for everyone. Individuals who are allergic to aceclidine or any of the drop’s ingredients should not use it. Patients with narrow-angle glaucoma or a history of retinal detachment are also advised to avoid this medication. Similarly, those suffering from ongoing eye infections or inflammation should consult their doctor before use. Pregnant and breastfeeding women are generally cautioned against Vizz unless specifically prescribed by a physician.

How to Use Vizz?

Vizz is designed to be simple and convenient. It is used once daily, with one drop instilled in each eye from a single-use vial. The improved vision begins within 30 minutes and lasts for up to 10 hours. For those who wear contact lenses, it is recommended to wait 10 minutes after applying the drop before reinserting lenses. Patients should avoid driving or operating heavy machinery until they are sure their vision is stable and clear.

Availability of Vizz

Following FDA approval, samples are expected in the U.S. by October 2025, with full commercial availability projected between November and December 2025. Vizz will be available only by prescription from eye care professionals, ensuring that patients receive the proper evaluation before use.

A Paradigm Shift in Presbyopia Care

Presbyopia affects nearly every adult over 45, and until now, the available solutions were mostly external aids such as glasses or contact lenses. Vizz introduces a pharmacological approach that is fast, effective, and convenient. It provides an excellent alternative for people who dislike glasses or contact lenses and may well become the new standard of care for presbyopia.

The approval of Vizz eye drops represents a historic breakthrough in ophthalmology. With its once-daily convenience, long-lasting effectiveness, and strong safety profile, Vizz has the potential to transform how millions of adults manage near vision loss. For those over 45 struggling with blurry near vision, a consultation with an ophthalmologist could be the first step toward embracing this groundbreaking innovation.